Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53

Morris, J. , Nixon, C., Bruck, A., Nasir, L., Morgan, I.M. and Philbey, A. (2008) Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERα and p53. Veterinary Journal, 175(2), pp. 218-226. (doi:10.1016/j.tvjl.2007.01.006)

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Abstract

The immunohistochemical expression of topoisomerase IIβ binding protein 1 (TopBP1) was examined in 123 feline mammary lesions (18 non-neoplastic lesions including six fibroadenomatous hyperplasia and 12 duct ectasia, 17 adenomas and 88 carcinomas) in relation to histological grade, oestrogen receptor α (ERα) status, proliferation index (Ki67) and p53 expression. There was positive staining for TopBP1 in 122 of 123 feline mammary lesions, although nine samples had fewer than 20% positive cells. The percentage of cells positive for TopBP1 increased with histological grade. Most staining was nuclear but both nuclear and cytoplasmic staining was observed as the degree of malignancy increased. TopBP1 is expressed in feline mammary tumours and its expression is correlated with histological grade. Many neoplasms which over-express p53 or are ERα negative show TopBP1 immunoreactivity. Keywords: Feline; Mammary tumours; TopBP1; Ki67; ERα; p53; Immunohistochemistry

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Professor Joanna and Nixon, Mr Colin and Philbey, Dr Adrian and Nasir, Professor Lubna and Morgan, Professor Iain
Authors: Morris, J., Nixon, C., Bruck, A., Nasir, L., Morgan, I.M., and Philbey, A.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Journal
Publisher:Elsevier Ltd
ISSN:1090-0233
ISSN (Online):1532-2971

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