Modulation of natural killer cells by human cytomegalovirus

Wilkinson, G.W.G. et al. (2008) Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology, 41(3), pp. 206-212. (doi:10.1016/j.jcv.2007.10.027) (PMID:18069056) (PMCID:PMC2843162)

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Abstract

Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is under intense, continuous selective pressure from the immune system. A key aspect of HCMV's capacity for survival lies in immune avoidance. In this context, cells undergoing productive infection exhibit remarkable resistance to natural killer (NK) cell-mediated cytolysis in vitro. To date, six genes encoding proteins (UL16, UL18. UL40. UL83, UL141 and UL142) and one encoding a nticroRNA (miR-UL112) have been identified as capable of suppressing NK cell recognition. Even though HCMV infection efficiently activates expression of ligands for the NK cell activating receptor NKG2D), at least three functions (UL16 UL142 and miR-UL112) act in concert to suppress presentation of these ligands on the cell surface. Although HCMV downregulates expression of endogenous MHC-I, it encodes an MHC-I homologue (UL18) and also upregulates the expression of cellular HLA-E through the action of UL40. The disruption of normal intercellular connections exposes ligands for NK cell activating receptors on the cell surface, notably CD155. HCMV overcomes this vulnerability by encoding a function (UL141) that acts post-translationally to suppress cell surface expression of CD155. The mechanisms by which HCMV systematically evades (or, more properly, modulates) NK cell recognition constitutes an area of growing understanding that is enhancing our appreciation of the basic mechanisms of NK cell function in humans. (C) 2007 Elsevier B.V. All rights reserved

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Davison, Professor Andrew
Authors: Wilkinson, G.W.G., Tomasec, P., Stanton, R.J., Armstrong, M., Prod'homme, V., Aicheler, R., McSharry, B.P., Rickards, C.R., Cochrane, D., Llewellyn-Lacey, S., Wang, E.C.Y., Griffin, C.A., and Davison, A.J.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Clinical Virology
Publisher:Elsevier B.V.
ISSN:1386-6532
ISSN (Online):1873-5967
Published Online:15 February 2008

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH