Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles

Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J. and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi:10.1016/j.bmcl.2008.02.037)

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Publisher's URL: http://dx.doi.org/10.1016/j.bmcl.2008.02.037

Abstract

A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muller, Professor Sylke and Barrett, Professor Michael
Authors: Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J., and Sutherland, A.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-894X

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