Nic An Ultaigh, S., Carolan, J. C., Britton, C. , Murray, L. and Ryan, M. F. (2009) A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1. Experimental Parasitology, 121(4), pp. 293-299. (doi: 10.1016/j.exppara.2008.11.002) (PMID:19059238)
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Abstract
Cathespin L-like proteases (CPLs), characterized from a wide range of helminths, are significant in helminth biology. For example, in Caenorhabditis elegans CPL is essential for embryogenesis. Here, we report a cathepsin L-like gene from three species of strongyles that parasitize the horse, and describe the isolation of a cpl gene (Sv-cpl-1) from Strongylus vulgaris, the first such from equine strongyles. It encodes a protein of 354 amino acids with high similarity to other parasitic Strongylida (9091%), and C. elegans CPL-1 (87%), a member of the same Clade. As S. vulgaris cpl-1 rescued the embryonic lethal phenotype of the C. elegans cpl-1 mutant, these genes may be orthologues, sharing the same function in each species. Targeting Sv-CPL-1 might enable novel control strategies by decreasing parasite development and transmission.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Britton, Professor Collette and Murray, Ms Linda |
Authors: | Nic An Ultaigh, S., Carolan, J. C., Britton, C., Murray, L., and Ryan, M. F. |
Subjects: | Q Science > Q Science (General) |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Experimental Parasitology |
Publisher: | Elsevier |
ISSN: | 0014-4894 |
ISSN (Online): | 1090-2449 |
Published Online: | 18 November 2008 |
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