Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction

Palmer, T.M. and Trevethick, M.A. (2008) Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. British Journal of Pharmacology, 153, S27-S34. (doi: 10.1038/sj.bjp.0707524) (PMID:18026131)

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The purine nucleoside adenosine has been described as a 'retaliatory metabolite' by virtue of its ability to function in an autocrine manner to modify the activity of a range of cell types following its extracellular accumulation during cell stress or injury. These effects are largely protective and are triggered by the binding of adenosine to any of four G-protein-coupled adenosine receptors. Most of the anti-inflammatory effects of adenosine have been assigned to the adenosine A(2A) receptor subtype, which is expressed in many immune and inflammatory cells. In this brief article, we will outline the growing evidence to support the hypothesis that the development of agonists selective for the A2A receptor is an effective strategy for suppressing the exaggerated inflammatory responses associated with many diseases by virtue of the receptor's ability to inhibit multiple pro-inflammatory signalling cascades

Item Type:Articles
Glasgow Author(s) Enlighten ID:Palmer, Dr Timothy
Authors: Palmer, T.M., and Trevethick, M.A.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:British Journal of Pharmacology
Publisher:Nature Publishing Group
ISSN (Online):1476-5381
Published Online:29 January 2009

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