Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct

Milner-White, E.J. and Russell, M. (2008) Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct. Biology Direct, 3(3), pp. 1-9. (doi:10.1186/1745-6150-3-3)

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Publisher's URL: http://dx.doi.org/10.1186/1745-6150-3-3

Abstract

Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milner-White, Professor E
Authors: Milner-White, E.J., and Russell, M.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Biology Direct
Publisher:BioMed Central
ISSN:1745-6150
Copyright Holders:2008 © Copyright BioMed Central
First Published:First published in Biology Direct 3(3):1-9
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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