Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3

Srikanth, C.V., Wall, D.M. , Maldonado-Contreras, A., Shi, H.N., Zhou, D.G., Demma, Z., Mumy, K.L. and Mccormick, B.A. (2010) Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3. Science, 330(6002), pp. 390-393. (doi: 10.1126/science.1194598)

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Abstract

The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms of inflammation or bacterial entry. During infection of intestinal epithelial cells, SipA was found to be responsible for the early activation of caspase-3, an enzyme that is required for SipA cleavage at a specific recognition motif that divided the protein into its two functional domains and activated SipA in a manner necessary for pathogenicity. Other caspase-3 cleavage sites identified in S. Typhimurium appeared to be restricted to secreted effector proteins, which indicates that this may be a general strategy used by this pathogen for processing of its secreted effectors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wall, Dr Daniel
Authors: Srikanth, C.V., Wall, D.M., Maldonado-Contreras, A., Shi, H.N., Zhou, D.G., Demma, Z., Mumy, K.L., and Mccormick, B.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
ISSN (Online):1095-9203
Published Online:15 October 2010
Copyright Holders:Copyright © 2010 American Association for the Advancement of Science
First Published:First published in Science 330(6002):390-393
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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