Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training

Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L. and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi:10.1097/HJR.0b013e3282efd4e0)

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Publisher's URL: http://dx.doi.org/10.1097/HJR.0b013e3282efd4e0

Abstract

Objective Reduced activity of the sarcoplasmic reticulum Ca2+ ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca2+-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training. Methods SERCA-2a function was assessed by sarcoplasmic reticulum Ca2+ uptake in cardiornyocytes with other Ca2+ uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls. Results We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca2+ uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio. Conclusion Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca2+-handling improves after exercise training.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Godfrey and Kemi, Dr Ole
Authors: Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U.
Subjects:Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:European Journal of Cardiovascular Prevention and Rehabilitation
ISSN:1741-8267

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