Definition of a conserved immunodominant domain on HCV E2 glycoprotein by neutralizing human monoclonal antibodies

Keck, Z.Y., Li, T.K., Xia, J., Gal-Tanamy, M., Olson, O., Li, S.H., Patel, A.H. , Ball, J.K., Lemon, S.M. and Foung, S.K.H. (2008) Definition of a conserved immunodominant domain on HCV E2 glycoprotein by neutralizing human monoclonal antibodies. Journal of Virology, 82(12), pp. 6061-6066. (doi:10.1128/JVI.02475-07)

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Publisher's URL: http://dx.doi.org/10.1128/JVI.02475-07

Abstract

Development of a successful hepatitis C virus (HCV) vaccine requires definition of neutralization epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previously designated as domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing HCV E1E2 glycoproteins, as well as infectious chimeric genotype 1a and genotype 2a virus. Alanine substitutions of residues within a region of E2 involved in binding to CD81 showed that critical E2 contact residues involved in the binding of representative antibodies are identical to those involved in binding of E2 to CD81.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Professor Arvind
Authors: Keck, Z.Y., Li, T.K., Xia, J., Gal-Tanamy, M., Olson, O., Li, S.H., Patel, A.H., Ball, J.K., Lemon, S.M., and Foung, S.K.H.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
ISSN:0022-538X
ISSN (Online):1098-5514
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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