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Multiple ADH genes are associated with upper aerodigestive cancers

Hashibe, M. et al. (2008) Multiple ADH genes are associated with upper aerodigestive cancers. Nature Genetics, 40(6), pp. 707-709. (doi: 10.1038/ng.151)

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Publisher's URL: http://dx.doi.org/10.1038/ng.151

Abstract

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six <i>ADH</i> genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (<i>ADH1B</i>) and rs1573496 (<i>ADH7</i>) were significantly protective against aerodigestive cancer in each individual study and overall (<i>P</i> = 10<sup>−10</sup> and 10<sup>−9</sup>, respectively). These effects became more apparent with increasing alcohol consumption (<i>P</i> for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple <i>ADH</i> genes may be involved in upper aerodigestive cancer etiology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Conway, Professor David
Authors: Hashibe, M., McKay, J. D., Curado, M. P., Oliveira, J. C., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V., Eluf-Neto, J., Levi, J. E., Matos, E., Lagiou, P., Lagiou, A., Benhamou, S., Bouchardy, C., Szeszenia-Dabrowska, N., Menezes, A., Dall'Agnol, M. M., Merletti, F., Richiardi, L., Fernandez, L., Lence, J., Talamini, R., Barzan, L., Mates, D., Mates, I. N., Kjaerheim, K., Macfarlane, G. J., Macfarlane, T. V., Simonato, L., Canova, C., Holcátová, I., Agudo, A., Castellsagué, X., Lowry, R., Janout, V., Kollarova, H., Conway, D. I., McKinney, P. A., Znaor, A., Fabianova, E., Bencko, V., Lissowska, J., Chabrier, A., Hung, R. J., Gaborieau, V., Boffetta, P., and Brennan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Nature Genetics
Publisher:Nature Publishing Group
ISSN:1061-4036
ISSN (Online):1546-1718
Published Online:25 May 2008
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