Xu, B., Guo, X., Mathew, S., Armesilla, A. L., Cassidy, J., Darling, J. L. and Wang, W. (2010) Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Letters, 291(2), pp. 200-208. (doi: 10.1016/j.canlet.2009.10.013)
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Publisher's URL: http://dx.doi.org/10.1016/j.canlet.2009.10.013
Abstract
The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51 nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low concentration of PG490. CI-isobologram indicated that the effect of PG490 plus 5-FU was synergistic. PG490 and 5-FU treatment induced activated caspase 3 and Bax expression and inhibited Bcl-2 expression. PG490 simultaneously induced generation of reactive oxygen species (ROS) and inhibited NF-kappa B transcriptional activity. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cassidy, Professor James |
Authors: | Xu, B., Guo, X., Mathew, S., Armesilla, A. L., Cassidy, J., Darling, J. L., and Wang, W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Cancer Letters |
ISSN: | 0304-3835 |
Published Online: | 01 January 2010 |
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