Runx2 in normal tissues and cancer cells: A developing story

Blyth, K. , Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A. , Huser, C. , Stein, T., Neil, J. and Cameron, E. R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases, 45(2), pp. 117-123. (doi:10.1016/j.bcmd.2010.05.007)

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Abstract

The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBFbeta, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stein, Dr Torsten and Blyth, Professor Karen and Cameron, Professor Ewan and Neil, Professor James and Mcdonald, Mrs Alma and McDonald, Miss Laura Ann and Pringle, Mrs Marie and Huser, Dr Camille
Authors: Blyth, K., Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A., Huser, C., Stein, T., Neil, J., and Cameron, E. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Blood Cells, Molecules, and Diseases
Publisher:Elsevier Inc.
ISSN:1079-9796
ISSN (Online):1096-0961
Published Online:02 July 2010

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