Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography

Berry, C.C. , McCloy, D. and Affrossman, S. (2008) Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography. Current Nanoscience, 4(2), pp. 219-223.

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Publisher's URL: http://www.ingentaconnect.com/content/ben/cnano/2008/00000004/00000002/art00015

Abstract

The use of three dimensional scaffolds in tissue engineering is well reported, as is the exploitation of nanotopography to influence cell response. To date, due to fabrication limitations, the combination of these two has experienced limited research. This paper reports on the use of polymer demixing, a rapid and cheap nanofabrication method, to create a defined nanotopography in 0.5mm diameter nylon tubes. Results indicate that the resultant nano-island topography reduced endothelial cell adhesion and spreading, strongly influenced cell morphology, and appeared to increase endocytic activity. The use of such constructs that boast topographical cues have great potential in tissue and cell engineering studies for future clinical use, in particular with respect to conduits and stents.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Dr Catherine and McCloy, Mr David
Authors: Berry, C.C., McCloy, D., and Affrossman, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Nanoscience
Publisher:BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
ISSN:1573-4137
Published Online:01 January 2008

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