Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography

Berry, C.C. , McCloy, D. and Affrossman, S. (2008) Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography. Current Nanoscience, 4(2), pp. 219-223.

Abstract

The use of three dimensional scaffolds in tissue engineering is well reported, as is the exploitation of nanotopography to influence cell response. To date, due to fabrication limitations, the combination of these two has experienced limited research. This paper reports on the use of polymer demixing, a rapid and cheap nanofabrication method, to create a defined nanotopography in 0.5mm diameter nylon tubes. Results indicate that the resultant nano-island topography reduced endothelial cell adhesion and spreading, strongly influenced cell morphology, and appeared to increase endocytic activity. The use of such constructs that boast topographical cues have great potential in tissue and cell engineering studies for future clinical use, in particular with respect to conduits and stents.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Berry, Dr Catherine and McCloy, Mr David
• Authors: Berry, C.C., McCloy, D., and Affrossman, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Current Nanoscience
• Publisher: BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
• ISSN: 1573-4137
• Published Online: 01 January 2008