Enhancement of Human Bone Marrow Cell Uptake of Quantum Dots using Tat Peptide

Berry, C.C. , Harianawalw, H., Loebus, J., Oreffo, R.O. and de la Fuente, J. (2009) Enhancement of Human Bone Marrow Cell Uptake of Quantum Dots using Tat Peptide. Current Nanoscience, 5(4), pp. 390-395.

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Publisher's URL: http://bentham.org/cnano/sample/cnano5-4/cnano5-4/D0001N.pdf

Abstract

Nanotechnology is proving to play a major role in the future of biomedical applications such as drug delivery, gene therapy and cell imaging/tracking, in particular the use of nanoparticles is regularly highlighted. However with regards to nanoparticles, direct intracellular and intranuclear delivery has, until recently, been difficult to achieve due to the impermeable nature of the plasma and nuclear membranes. The advent of cell penetrating peptides being employed as delivery vectors has opened up many avenues with respect to targeted delivery systems. In this paper, quantum dots were synthesised and functionalised with the HIV-1 tat peptide, and uptake into human bone marrow derived cell populations was assessed. Results demonstrated an increase in uptake for tat modified quantum dots, possibly via a different mechanism to non-modified dots.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Dr Catherine
Authors: Berry, C.C., Harianawalw, H., Loebus, J., Oreffo, R.O., and de la Fuente, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Nanoscience
Publisher:BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
ISSN:1573-4137
Published Online:01 January 2009

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