Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species

Al-Dhaheri, R.S. and Douglas, L.J. (2008) Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species. Antimicrobial Agents and Chemotherapy, 52(5), pp. 1884-1887. (doi:10.1128/AAC.01473-07)

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Publisher's URL: http://dx.doi.org/10.1128/AAC.01473-07

Abstract

Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential- or stationary-phase) contained persister cells. However, persisters were found in biofilms of one of two strains of C. albicans tested, and in biofilms of C. krusei and C. parapsilosis, but not in biofilms of C. glabrata or C. tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Douglas, Dr Lisbeth
Authors: Al-Dhaheri, R.S., and Douglas, L.J.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Antimicrobial Agents and Chemotherapy
Journal Abbr.:Antimicrob Agents Chemother
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596

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