Catalysis of site-specific recombination by Tn3 resolvase

Olorunniji, F.J. and Stark, W.M. (2010) Catalysis of site-specific recombination by Tn3 resolvase. Biochemical Society Transactions, 38(2), pp. 417-421. (doi: 10.1042/BST0380417) (PMID:20298194)

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The active-site interactions involved in the catalysis of DNA site-specific recombination by the serine recombinases are still incompletely understood. Recent crystal structures of synaptic gammadelta resolvase-DNA intermediates and biochemical analysis of Tn3 resolvase mutants have provided new insights into the structure of the resolvase active site, and how interactions of the catalytic residues with the DNA substrate might promote the phosphoryl transfer reactions.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Stark, Professor Marshall and Olorunniji, Dr Femi
Authors: Olorunniji, F.J., and Stark, W.M.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Biochemical Society Transactions

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
448811The mechanism of DNA strand exchange by serine recombinasesWilliam StarkBiotechnology and Biological Sciences Research Council (BBSRC)BB/E022200/1Institute of Molecular Cell and Systems Biology