Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial

Barrett, S.V., Paul, J. , Hay, A., Vasey, P.A., Kaye, S.B. and Glasspool, R.M. (2008) Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial. Annals of Oncology, 19(5), pp. 898-902. (doi:10.1093/annonc/mdm606)

Barrett, S.V., Paul, J. , Hay, A., Vasey, P.A., Kaye, S.B. and Glasspool, R.M. (2008) Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial. Annals of Oncology, 19(5), pp. 898-902. (doi:10.1093/annonc/mdm606)

Full text not currently available from Enlighten.

Abstract

Background: Previous studies have indicated an association between obesity and poor survival in several tumour types, including ovarian cancer. We sought to test the hypothesis that obesity reduces survival in a large, well-characterised and relatively homogeneous cohort of ovarian cancer patients. Patients and methods: The relationship between body mass index (BMI) and overall survival (OS) and progression-free survival (PFS) in 1067 patients participating in the Scottish Randomised Trial in Ovarian Cancer I trial was assessed. All patients received first-line carboplatin/taxane chemotherapy. The dose of carboplatin was determined by a measured glomerular filtration rate (GFR), ensuring accurate dosing in all categories of BMI and the dose of taxane was not capped. Patients were assigned to one of four categories: underweight (BMI < 18.5), ideal weight (BMI 18.5-24.9), overweight (BMI 25-29.9) or obese (BMI >= 30). Results: There were neither statistically significant differences in PFS or OS between these four groups nor were there any differences in taxane or carboplatin dose intensity. Furthermore, there was no association between BMI and tumour stage or grade at presentation, or completeness of debulking surgery. Conclusions: Obese patients with epithelial ovarian cancer do not have a poorer prognosis, provided that they receive optimal doses of chemotherapy based on measured GFR and actual body weight.

Item Type:Articles
Additional Information:Times Cited: 9
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paul, Mr James
Authors: Barrett, S.V., Paul, J., Hay, A., Vasey, P.A., Kaye, S.B., and Glasspool, R.M.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Annals of Oncology
Journal Abbr.:Ann. Oncol.
ISSN:0923-7534
ISSN (Online):1569-8041
Published Online:13 February 2008

University Staff: Request a correction | Enlighten Editors: Update this record