varDB: common ground for a shifting landscape

Allred, D.R., Barbet, A.F., Barry, J.D. and Deitsch, K.W. (2009) varDB: common ground for a shifting landscape. Trends in Parasitology, 25(6), pp. 249-52. (doi:10.1016/j.pt.2009.03.003)

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Abstract

Antigenic variation is a phylogenetically widespread phenomenon thought to lead to survival benefits for the pathogen. Although governed by genetic mechanisms, antigenic variation is ultimately manifested in variant proteins. The varDB database is an attempt to gain an overview of common structures and functions of variant proteins related to enhanced survival. varDB provides a wealth of sequence data and several tools to facilitate their analysis, but current limitations preclude achievement of its full promise. A critique of this database and how it could serve the scientific community is provided here.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barry, Professor Dave
Authors: Allred, D.R., Barbet, A.F., Barry, J.D., and Deitsch, K.W.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
Publisher:Elsevier Ltd., Trends Journals
ISSN:1471-4922
ISSN (Online):1471-5007

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