G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

Milligan, G. (2009) G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. British Journal of Pharmacology, 158(1), pp. 5-14. (doi: 10.1111/j.1476-5381.2009.00169.x) (PMID:19309353) (PMCID:PMC2795239)

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Publisher's URL: http://dx.doi.org/10.1111/j.1476-5381.2009.00169.x


The concept that G protein-coupled receptors (GPCRs) can form hetero-dimers or hetero-oligomers continues to gain experimental support. However, with the exception of the GABAB receptor and the sweet and umami taste receptors few reported examples meet all of the criteria suggested in a recent International Union of Basic and Clinical Pharmacology sponsored review (Pin et al., 2007) that should be required to define distinct and physiologically relevant receptor species. Despite this, there are many examples in which pairs of co-expressed GPCRs reciprocally modulate their function, trafficking and/or ligand pharmacology. Such data are at least consistent with physical interactions between the receptor pairs. In recent times, it has been suggested that specific GPCR hetero-dimer or hetero-oligomer pairs may represent key molecular targets of certain clinically effective, small molecule drugs and there is growing interest in efforts to identify ligands that may modulate hetero-dimer function selectively. The current review summarizes key recent developments in these topics.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Milligan, Professor Graeme
Authors: Milligan, G.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:British Journal of Pharmacology
Journal Abbr.:BJP
Publisher:John Wiley & Sons Ltd.
ISSN (Online):1476-5381
Published Online:20 March 2009
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