Activity-dependent gene transcription as a long-term influence on receptor signalling

McDade, D.M., Conway, A.M., James, A.B. and Morris, B.J. (2009) Activity-dependent gene transcription as a long-term influence on receptor signalling. Biochemical Society Transactions, 37(6), pp. 1375-1377. (doi:10.1042/BST0371375)

McDade, D.M., Conway, A.M., James, A.B. and Morris, B.J. (2009) Activity-dependent gene transcription as a long-term influence on receptor signalling. Biochemical Society Transactions, 37(6), pp. 1375-1377. (doi:10.1042/BST0371375)

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Abstract

The regulation of synaptic glutamate receptor and GABAAR (γ -aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction of the transcription factor zif268 (egr1). Hence, it is predicted that zif268 may regulate transcription of genes associated with glutamate receptors and/or GABAARs. It turns out that receptor regulation by zif268 tends to be indirect. Induction of zif268 in neurons leads to altered expression of proteasome subunit and proteasome-regulatory genes, thereby changing the capacity of the neuron to degrade synaptic proteins, including receptors and receptor subunits. In addition, zif268 alters the transcription of genes associated with GABAAR expression and trafficking, such as ubiquilin and gephyrin. This indirect regulation of receptor turnover is likely to contribute to the delayed, but long-lasting, phases of synaptic plasticity and also to the synaptic dysfunction associated with diseases such as schizophrenia and Alzheimer’s disease, where zif268 expression is reduced.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McDade, Ms Donna and Morris, Professor Brian and James, Dr Allan
Authors: McDade, D.M., Conway, A.M., James, A.B., and Morris, B.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Biochemical Society Transactions
ISSN:0300-5127
ISSN (Online):1470-8752

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