Coenzyme Q10, Rosuvastatin, and Clinical Outcomes in Heart FailureA Pre-Specified Substudy of CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure)

McMurray, J.J.V. , Dunselman, P., Wedel, H., Cleland, J.G.F., Lindberg, M., Hjalmarson, Å., Kjekshus, J., Waagstein, F., Apetrei, E. and Barrios, V. (2010) Coenzyme Q10, Rosuvastatin, and Clinical Outcomes in Heart FailureA Pre-Specified Substudy of CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure). Journal of the American College of Cardiology, 56(15), pp. 1196-1204. (doi: 10.1016/j.jacc.2010.02.075)

Abstract

Objectives The purpose of this study was to determine whether coenzyme Q(10) is an independent predictor of prognosis in heart failure. Background Blood and tissue concentrations of the essential cofactor coenzyme Q(10) are decreased by statins, and this could be harmful in patients with heart failure. Methods We measured serum coenzyme Q(10) in 1,191 patients with ischemic systolic heart failure enrolled in CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure) and related this to clinical outcomes. Results Patients with lower coenzyme Q(10) concentrations were older and had more advanced heart failure. Mortality was significantly higher among patients in the lowest compared to the highest coenzyme Q(10) tertile in a univariate analysis (hazard ratio: 1.50, 95% confidence interval: 1.04 to 2.6, p = 0.03) but not in a multivariable analysis. Coenzyme Q(10) was not an independent predictor of any other clinical outcome. Rosuvastatin reduced coenzyme Q(10) but there was no interaction between coenzyme Q(10) and the effect of rosuvastatin. Conclusions Coenzyme Q(10) is not an independent prognostic variable in heart failure. Rosuvastatin reduced coenzyme Q(10), but even in patients with a low baseline coenzyme Q(10), rosuvastatin treatment was not associated with a significantly worse outcome.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: McMurray, J.J.V., Dunselman, P., Wedel, H., Cleland, J.G.F., Lindberg, M., Hjalmarson, Å., Kjekshus, J., Waagstein, F., Apetrei, E., and Barrios, V.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences
• Journal Name: Journal of the American College of Cardiology
• Publisher: Elsevier Inc.
• ISSN: 0735-1097