Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

Reid, C. M., Ebikeme, C., Barrett, M.P. , Patzewitz, E.-M., Muller, S., Robins, D. J. and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi: 10.1016/j.bmcl.2008.09.047)

Abstract

Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti-protozoal activity against trypanosomes

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Muller, Professor Sylke and Barrett, Professor Michael
• Authors: Reid, C. M., Ebikeme, C., Barrett, M.P., Patzewitz, E.-M., Muller, S., Robins, D. J., and Sutherland, A.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• ISSN: 0960894X