Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

Reid, C. M., Ebikeme, C., Barrett, M.P. , Patzewitz, E.-M., Muller, S., Robins, D. J. and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi:10.1016/j.bmcl.2008.09.047)

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Publisher's URL: http://dx.doi.org/10.1016/j.bmcl.2008.09.047

Abstract

Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti-protozoal activity against trypanosomes

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muller, Professor Sylke and Barrett, Professor Michael
Authors: Reid, C. M., Ebikeme, C., Barrett, M.P., Patzewitz, E.-M., Muller, S., Robins, D. J., and Sutherland, A.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960894X

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