Paromomycin: Uptake and resistance in Leishmania donovani

Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P. and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi:10.1016/j.molbiopara.2008.12.007)

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Publisher's URL: http://dx.doi.org/10.1016/j.molbiopara.2008.12.007

Abstract

Paromomycin is currently in phase IV clinical trials against leishmaniasis. In the present work we elucidate the effect and mechanism of uptake of paromomycin in Leishmania donovani. The in vitro sensitivities of both promastigotes and amastigotes were determined to this aminoglycoside. Association of paromomycin with L. donovani involved a rapid initial phase that was non-saturable up to 1

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barrett, Professor Michael
Authors: Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P., and Madhubala, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN:0166-6851
ISSN (Online):1872-9428

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