Diamidines for human African trypanosomiasis

Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.

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Publisher's URL: http://www.biomedcentral.com/1472-4472/11/876


Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed

Item Type:Articles
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry and Barrett, Professor Michael
Authors: Paine, M.F., Wang, M.Z., Generaux, C.N., Boykin, D.W., Wilson, W.D., De Koning, H.P., Olson, C.A., Pohlig, G., Burri, C., Brun, R., Murilla, G.A., Thuita, J.K., Barrett, M.P., and Tidwell, R.R.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Investigational Drugs
Published Online:21 July 2010
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