N-glycan production in the endoplasmic reticulum of plants

Pattison, R. J. and Amtmann, A. (2009) N-glycan production in the endoplasmic reticulum of plants. Trends in Plant Science, 14(2), pp. 92-99. (doi: 10.1016/j.tplants.2008.11.008)

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Publisher's URL: http://dx.doi.org/10.1016/j.tplants.2008.11.008

Abstract

N-glycosylation is a complex process that encompasses the biosynthesis and modification of sugar moieties in the endoplasmic reticulum (ER) and Golgi. The ER-localized steps of N-glycan production in plants have received relatively little attention, despite their emerging roles in stress responses. Here, we integrate information on the molecular components underlying the three stages of N-glycan production: lipid-linked oligosaccharide synthesis, co-translational oligosaccharyl-transfer and quality control of the folded glycoprotein in the ER. The relative importance of each step for N-glycosylation and plant performance is evaluated on the basis of studies with inhibitors and mutant phenotypes. Finally, we highlight the increasing evidence for crosstalk between N-glycan production and defence responses in plants and discuss the practical implications for pathogen resistance

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Amtmann, Professor Anna
Authors: Pattison, R. J., and Amtmann, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Trends in Plant Science
ISSN:13601385

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