Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice

Yau, J.L.W., McNair, K.M., Noble, J., Brownstein, D., Hibberd, C., Morton, N., Mullins, J.J., Morris, R.G.M., Cobb, S. and Seckl, J.R. (2007) Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice. Journal of Neuroscience, 27(39), pp. 10487-10496. (doi:10.1523/JNEUROSCI.2190-07.2007)

[img]
Preview
Text
Cobb4086.pdf

495kB

Publisher's URL: http://dx.doi.org/10.1523/JNEUROSCI.2190-07.2007

Abstract

Glucocorticoids are pivotal in the maintenance of memory and cognitive functions as well as other essential physiological processes including energy metabolism, stress responses, and cell proliferation. Normal aging in both rodents and humans is often characterized by elevated glucocorticoid levels that correlate with hippocampus-dependent memory impairments. 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) amplifies local intracellular ("intracrine") glucocorticoid action; in the brain it is highly expressed in the hippocampus. We investigated whether the impact of 11ß-HSD1 deficiency in knock-out mice (congenic on C57BL/6J strain) on cognitive function with aging reflects direct CNS or indirect effects of altered peripheral insulin-glucose metabolism. Spatial learning and memory was enhanced in 12 month "middle-aged" and 24 month "aged" 11ß-HSD1–/– mice compared with age-matched congenic controls. These effects were not caused by alterations in other cognitive (working memory in a spontaneous alternation task) or affective domains (anxiety-related behaviors), to changes in plasma corticosterone or glucose levels, or to altered age-related pathologies in 11ß-HSD1–/– mice. Young 11ß-HSD1–/– mice showed significantly increased newborn cell proliferation in the dentate gyrus, but this was not maintained into aging. Long-term potentiation was significantly enhanced in subfield CA1 of hippocampal slices from aged 11ß-HSD1–/– mice. These data suggest that 11ß-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis.

Item Type:Articles
Keywords:Glucocorticoids, memory, ageing, neurogenesis, LTP, hippocampus.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cobb, Dr Stuart and McNair, Mrs Kara
Authors: Yau, J.L.W., McNair, K.M., Noble, J., Brownstein, D., Hibberd, C., Morton, N., Mullins, J.J., Morris, R.G.M., Cobb, S., and Seckl, J.R.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Journal of Neuroscience
Publisher:The Society for Neuroscience
ISSN:0270-6474
Copyright Holders:Copyright © 2007 The Society for Neuroscience
First Published:First published in Journal of Neuroscience 27(39):10487-10496
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

University Staff: Request a correction | Enlighten Editors: Update this record