The cardiac contraction cycle: is Ca2+ going local?

Fowler, M. and Smith, G.L. (2009) The cardiac contraction cycle: is Ca2+ going local? Journal of Applied Physiology, 107(6), pp. 1981-1984. (doi: 10.1152/japplphysiol.91168.2009)

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The myriad of intracellular signalling pathways involving intracellular Ca2+ means Ca2+ plays a role in everything from cellular metabolism to cell death. In heart muscle Ca2+ is primarily known for its role in cellular contraction. Regulation of cardiac muscle contractility is achieved through modulation of the spatio-temporal nature of intracellular Ca2+ signals, operating in areas of restricted diffusion or microdomains, close to Ca2+ release sites. This Viewpoint article briefly integrates experimental evidence in support of this concept.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Smith, Professor Godfrey and Fowler, Dr Mark
Authors: Fowler, M., and Smith, G.L.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Applied Physiology
Published Online:19 March 2009

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