The EspF effector - a bacterial pathogen's Swiss army knife

Holmes, A., Muhlen, S., Roe, A.J. and Dean, P. (2010) The EspF effector - a bacterial pathogen's Swiss army knife. Infection and Immunity, 78(11), pp. 4445-4453. (doi:10.1128/IAI.00635-10)

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Publisher's URL: http://dx.doi.org/10.1128/IAI.00635-10

Abstract

Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector proteins directly into the cells of their eukaryotic host. EspF is one of many effector proteins exclusive to the attaching and effacing pathogen family that includes enteropathogenic (EPEC) and enterohemorrhagic E. coli (EHEC). Work in recent years has revealed EspF to be one of the most multi-functional effector proteins known, with defined roles in several host cellular processes including disruption of the epithelial barrier, anti-phagocytosis, microvilli effacement, host membrane remodelling, modulation of the cytoskeleton, targeting and disruption of the nucleolus, intermediate filament disruption, cell invasion, mitochondrial dysfunction, apoptosis and the inhibition of several important epithelial transporters. Surprisingly, despite this high number of functions, EspF is a relatively small effector protein and recent work has begun to decipher the molecular events that underlie its multi-functionality. This review focuses on the activities of EspF within the host cell and discusses recent findings and molecular insights relating to the virulence functions of this fascinating bacterial effector

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roe, Professor Andrew
Authors: Holmes, A., Muhlen, S., Roe, A.J., and Dean, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Infection and Immunity
ISSN:0019-9567
Published Online:02 August 2010

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
535461Utility of LOV-based Fluorescent Reporters To Monitor the Real-Time Secretion and Localisation of Bacterial Effector ProteinsAndrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/H023518/1Infection Immunity and Inflammation Life Sciences
491441A biochemical and molecular analysis of the YhaO membrane protein in Escherichia coli O157:H7Andrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/G011389/1Infection Immunity and Inflammation Life Sciences