Mining cellular senescence for drug targets

Bilsland, A. E. and Keith, W. N. (2010) Mining cellular senescence for drug targets. In: Adams, P. D. and Sedivy, J. M. (eds.) Cellular Senescence and Tumor Suppression. Springer: New York, pp. 235-266. ISBN 9781441910745 (doi: 10.1007/978-1-4419-1075-2_10)

Abstract

One of the fundamental changes required for tumorigenesis is escape from cellular senescence. Strategies to induce senescence in cancer cells might provide future therapies complementary to existing interventions aimed at apoptosis. Progress toward senescence targeted drug discovery could be accelerated by applying novel screening-technologies and in particular, cell-based screening approaches to identifing and validating small molecule agonists/effectors or stabilisers of senescence. In this chapter, we review the molecular bases of cellular senescence from a drug discovery perspective, highlighting existing therapies that induce senescence and strategies to expand the pool of candidate molecular targets.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Bilsland, Dr Alan and Keith, Professor Nicol
• Authors: Bilsland, A. E., and Keith, W. N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Publisher: Springer
• ISBN: 9781441910745