Targeting telomerase for cancer therapeutics

Shay, J. W. and Keith, W. N. (2008) Targeting telomerase for cancer therapeutics. British Journal of Cancer, 98(4), pp. 677-683. (doi:10.1038/sj.bjc.6604209)

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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6604209

Abstract

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Keith, Professor Nicol
Authors: Shay, J. W., and Keith, W. N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:British Journal of Cancer
Journal Abbr.:Brit J Cancer
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:29 January 2008

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