Shay, J. W. and Keith, W. N. (2008) Targeting telomerase for cancer therapeutics. British Journal of Cancer, 98(4), pp. 677-683. (doi: 10.1038/sj.bjc.6604209)
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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6604209
Abstract
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Keith, Professor Nicol |
Authors: | Shay, J. W., and Keith, W. N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | British Journal of Cancer |
Journal Abbr.: | Brit J Cancer |
ISSN: | 0007-0920 |
ISSN (Online): | 1532-1827 |
Published Online: | 29 January 2008 |
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