Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties

Parenty, A.D.C., Smith, L.V., Guthrie, K.M., Long, D.-L. , Plumb, J., Brown, R. and Cronin, L. (2005) Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties. Journal of Medicinal Chemistry, 48(14), pp. 4504-4506. (doi:10.1021/jm050320z)

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Publisher's URL: http://dx.doi.org/10.1021/jm050320z

Abstract

A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parenty, Mr Alexis and Plumb, Dr Jane and Brown, Prof Robert and Long, Dr Deliang and Cronin, Professor Lee
Authors: Parenty, A.D.C., Smith, L.V., Guthrie, K.M., Long, D.-L., Plumb, J., Brown, R., and Cronin, L.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
University Centres > Glasgow Materials Research Initiative
Journal Name:Journal of Medicinal Chemistry
ISSN:0022-2623

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