Parenty, A.D.C., Smith, L.V., Guthrie, K.M., Long, D.-L. , Plumb, J., Brown, R. and Cronin, L. (2005) Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties. Journal of Medicinal Chemistry, 48(14), pp. 4504-4506. (doi: 10.1021/jm050320z)
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Publisher's URL: http://dx.doi.org/10.1021/jm050320z
Abstract
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Parenty, Mr Alexis and Plumb, Dr Jane and Brown, Prof Robert and Long, Dr Deliang and Cronin, Professor Lee |
Authors: | Parenty, A.D.C., Smith, L.V., Guthrie, K.M., Long, D.-L., Plumb, J., Brown, R., and Cronin, L. |
Subjects: | Q Science > QD Chemistry |
College/School: | College of Science and Engineering > School of Chemistry University Centres > Glasgow Materials Research Initiative |
Journal Name: | Journal of Medicinal Chemistry |
ISSN: | 0022-2623 |
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