Effects of GI vs content of cereal fibre of the evening meal on glucose tolerance at a subsequent standardized breakfast

Nilsson, A., Ostman, E., Preston, T. and Bjorck, I. (2008) Effects of GI vs content of cereal fibre of the evening meal on glucose tolerance at a subsequent standardized breakfast. European Journal of Clinical Nutrition, 62(6), pp. 712-720. (doi:10.1038/sj.ejcn.1602784)

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Abstract

<p>Objective: To investigate if the improved glucose tolerance previously observed at breakfast following an evening meal with boiled barley kernels derives from colonic events related to the fermentation of the elevated amounts of indigestible carbohydrates present and/or from the low-GI features.</p> <p>Subjects/Methods: Twenty healthy volunteers aged 19–30 years.</p> <p>Design: High-GI white wheat bread (WWB), WWB+barley dietary fibre (DF) corresponding to the DF content of barley kernels, low-GI spaghetti+ barley DF, spaghetti+double amounts of barley DF (2*DF), spaghetti+oat DF, or whole grain barley flour porridge, were provided as late evening meals. At a subsequent standardised WWB breakfast, B-glucose, s-insulin, p-SCFA, p-FFA, and breath hydrogen (H<sub>2</sub>) were measured.</p> <p>Results: The B-glucose response (incremental areas under the curves (IAUC) 0–120 min and total areas under the curves 0–180 min) to the standardized breakfast was significantly lower after consuming spaghetti+2*DF in the evening compared with barley porridge (<i>P</i>=0.012). The spaghetti+2*DF meal also resulted in the highest breath H2 excretion (<i>P</i><0.02). The glucose IAUC (0–120 min) after the standardized breakfast was positively correlated to fasting p-FFA (<i>r</i>=0.29, <i>P</i><0.02), and the total glucose area (0–180 min) was negatively correlated to the p-propionate level (0–30 min) (<i>r</i>=−0.24, <i>P</i><0.02).</p> <p>Conclusions: The prolonged digestive and absorptive phase per se, like with a low-glycaemic index (GI) spaghetti evening meal, did not induce overnight benefits on glucose tolerance. Addition of barley DF in high amounts (2*DF) was required to improve overnight glucose tolerance. The correlations observed between glycaemia and p-propionate implicate colonic fermentation as a modulator of glucose tolerance through a mechanism leading to suppressed free fatty acids levels. It is proposed that the overnight benefits on glucose tolerance previously reported for boiled barley kernels is mediated through colonic fermentation of the prebiotic carbohydrates present in this product.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Professor Thomas
Authors: Nilsson, A., Ostman, E., Preston, T., and Bjorck, I.
Subjects:Q Science > QP Physiology
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:European Journal of Clinical Nutrition
ISSN:0954-3007
ISSN (Online):1476-5640
Published Online:23 May 2007

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