Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

Smith, L.V., de la Fuente, J.M., Guthrie, K.M., Parenty, A.D.C. and Cronin, L. (2005) Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules. New Journal of Chemistry, 29, pp. 1118-1120. (doi:10.1039/b507037f)

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Publisher's URL: http://dx.doi.org/10.1039/b507037f

Abstract

Ultrafiltration analysis has been used to screen DNA oligonucleotide interactive small molecules for the first time, providing an almost instantaneous indication of the binding affinity, and was used to identify a new class of DNA interactive molecules based on a range of dihydro-imidazo-phenanthridinium-based framework; this methodology provides a straightforward yes/no answer to small molecule DNA binding.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parenty, Mr Alexis and Cronin, Professor Lee
Authors: Smith, L.V., de la Fuente, J.M., Guthrie, K.M., Parenty, A.D.C., and Cronin, L.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
University Centres > Glasgow Materials Research Initiative
Journal Name:New Journal of Chemistry
ISSN:1144-0546

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