CD23/FceRII: molecular multi-tasking

Acharya, M., Borland, G., Edkins, A.L., MacLellan, L.M., Matheson, J., Ozanne, B.W. and Cushley, W. (2010) CD23/FceRII: molecular multi-tasking. Clinical and Experimental Immunology, 162(1), pp. 12-23. (doi:10.1111/j.1365-2249.2010.04210.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2249.2010.04210.x

Abstract

CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cushley, Professor William
Authors: Acharya, M., Borland, G., Edkins, A.L., MacLellan, L.M., Matheson, J., Ozanne, B.W., and Cushley, W.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Clinical and Experimental Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0009-9104

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