Miller, A. M., Asquith, D. L., Hueber, A. J., Anderson, L. A., Holmes, W. M. , McKenzie, A. N., Xu, D., Sattar, N. , McInnes, I. B. and Liew, F. Y. (2010) Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circulation Research, 107(5), pp. 650-658. (doi: 10.1161/CIRCRESAHA.110.218867) (PMID:20634488) (PMCID:PMC4254700)
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Abstract
Rationale: Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear. Objective: To examine the functional role of IL-33 in adipose tissues and investigate the effects on adipose tissue inflammation and obesity in vivo. Methods and Results: We demonstrate that treatment of adipose tissue cultures in vitro with IL-33 induced production of Th2 cytokines (IL-5, IL-13, IL-10) and reduced expression of adipogenic and metabolic genes. Administration of recombinant IL-33 to genetically obese diabetic (ob/ob) mice led to reduced adiposity, reduced fasting glucose and improved glucose and insulin tolerance. IL-33 also induced accumulation of Th2 cells in adipose tissue and polarization of adipose tissue macrophages toward an M2 alternatively activated phenotype (CD206+), a lineage associated with protection against obesity-related metabolic events. Furthermore, mice lacking endogenous ST2 fed high-fat diet had increased body weight and fat mass and impaired insulin secretion and glucose regulation compared to WT controls fed high-fat diet. Conclusions: In conclusion, IL-33 may play a protective role in the development of adipose tissue inflammation during obesity.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liew, Prof Foo and McInnes, Professor Iain and Xu, Dr Damo and Asquith, Dr Darren and Miller, Dr Ashley and Holmes, Dr William and Hueber, Dr Axel and Sattar, Professor Naveed |
Authors: | Miller, A. M., Asquith, D. L., Hueber, A. J., Anderson, L. A., Holmes, W. M., McKenzie, A. N., Xu, D., Sattar, N., McInnes, I. B., and Liew, F. Y. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Circulation Research |
Publisher: | American Heart Association |
ISSN: | 0009-7330 |
Published Online: | 15 July 2010 |
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