Dalby, M.J. , Giannaras, D., Riehle, M.O. , Gadegaard, N. , Affrossman, S. and Curtis, A.S.G. (2004) Rapid fibroblast adhesion to 27 nm high polymer demixed nano-topography. Biomaterials, 25(1), pp. 77-83. (doi: 10.1016/S0142-9612(03)00475-7)
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Publisher's URL: http://dx.doi.org/10.1016/S0142-9612(03)00475-7
Abstract
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical method of producing nano-topography. This manuscript investigates human fibroblast response to 27 nm high nano-islands produced by polymer demixing. Cell spreading, cytoskeleton, focal adhesion and Rac localisation were studied. The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture.
Item Type: | Articles |
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Keywords: | Nano-topography, fibroblasts, cytoskeleton, cell adhesion. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Curtis, Professor Adam and Gadegaard, Professor Nikolaj and Dalby, Professor Matthew and Riehle, Dr Mathis |
Authors: | Dalby, M.J., Giannaras, D., Riehle, M.O., Gadegaard, N., Affrossman, S., and Curtis, A.S.G. |
Subjects: | R Medicine > R Medicine (General) T Technology > TP Chemical technology |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences University Centres > Glasgow Materials Research Initiative |
Journal Name: | Biomaterials |
ISSN: | 0142-9612 |
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