Fibroblast response to a controlled nanoenvironment produced by colloidal lithography

Dalby, M.J. , Riehle, M.O. , Sutherland, D.S., Agheli, H. and Curtis, A.S.G. (2004) Fibroblast response to a controlled nanoenvironment produced by colloidal lithography. Journal of Biomedical Materials Research Part A, 69A(2), pp. 314-322. (doi: 10.1002/jbm.a.20138)

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It is thought that by understanding how cells respond to topography, that better tissue engineering may be achievable. An important consideration in the cellular environment is topography. The effects of microtopography have been well documented, but the effects of nanotopography are less well known. Previously, methods of nanofabrication have been costly and time-consuming, but research by engineers, physicists, and chemists is starting to allow the production of nanostructures using low-cost techniques. In this report, nanotopography is specifically considered. Controlled patterns of 160 nm high nanocolumns were produced for in vitro cell culture using colloidal lithography. By studying cell adhesion with time and cytoskeletal (actin, tubulin, and vimentin) maturity, insight has been gained as to how fibroblasts adhere to these nanofeatures.

Item Type:Articles
Keywords:Nanobioscience, nanotopography, adhesion, cytoskeleton, fibroblast.
Glasgow Author(s) Enlighten ID:Curtis, Professor Adam and Dalby, Professor Matthew and Riehle, Dr Mathis
Authors: Dalby, M.J., Riehle, M.O., Sutherland, D.S., Agheli, H., and Curtis, A.S.G.
Subjects:R Medicine > R Medicine (General)
T Technology > TP Chemical technology
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
University Centres > Glasgow Materials Research Initiative
Journal Name:Journal of Biomedical Materials Research Part A

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