Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

McMillan, N., Smith, L.V., de la Fuente, J.M., Parenty, A.D.C., Gadegaard, N. , Pitt, A.R., Thomson, K., MacKenzie, C., Kelly, S. and Cronin, L. (2007) Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification. Chemical Communications, 25, pp. 2581-2583. (doi:10.1039/b702575k)

McMillan, N., Smith, L.V., de la Fuente, J.M., Parenty, A.D.C., Gadegaard, N. , Pitt, A.R., Thomson, K., MacKenzie, C., Kelly, S. and Cronin, L. (2007) Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification. Chemical Communications, 25, pp. 2581-2583. (doi:10.1039/b702575k)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1039/b702575k

Abstract

N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parenty, Mr Alexis and McMillan, Miss Nicola and Pitt, Dr Andrew and Gadegaard, Professor Nikolaj and Cronin, Professor Leroy
Authors: McMillan, N., Smith, L.V., de la Fuente, J.M., Parenty, A.D.C., Gadegaard, N., Pitt, A.R., Thomson, K., MacKenzie, C., Kelly, S., and Cronin, L.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
University Centres > Glasgow Materials Research Initiative
Journal Name:Chemical Communications
ISSN:1359-7345

University Staff: Request a correction | Enlighten Editors: Update this record