Parenty, A.D.C., Song, Y.-F., Richmond, C.J. and Cronin, L. (2007) A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring. Organic Letters, 9(12), pp. 2253-2256. (doi: 10.1021/ol070263z)
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Publisher's URL: http://dx.doi.org/10.1021/ol070263z
Abstract
A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of the pyridine ring, followed by a cascade reaction triggered by a nucleophilic attack of the iminium moiety. Depending on the pyridinium salt, it is possible to obtain functionalized imidazole moieties.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Parenty, Mr Alexis and Song, Dr Yufei and Cronin, Professor Lee |
| Authors: | Parenty, A.D.C., Song, Y.-F., Richmond, C.J., and Cronin, L. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry University Centres > Glasgow Materials Research Initiative |
| Journal Name: | Organic Letters |
| ISSN: | 1523-7060 |
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