C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine

Wilkins, J. A. and Sansom, O. J. (2008) C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine. Cancer Research, 68(13), pp. 4963-4966. (doi:10.1158/0008-5472.CAN-07-5558)

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Publisher's URL: http://dx.doi.org/10.1158/0008-5472.CAN-07-5558

Abstract

The Adenomatous polyposis coli (Apc) gene is mutated in up to 80% of sporadic colorectal cancers. After Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc. This review focuses on recent data highlighting the importance of the C-Myc oncogene and its transcriptional targets in establishing all of the phenotypes caused by the deletion of the Apc tumor suppressor gene within the intestinal epithelium. The importance of investigating Apc and C-Myc gene function in the correct tissue context is also discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sansom, Professor Owen
Authors: Wilkins, J. A., and Sansom, O. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cancer Research
ISSN:0008-5472

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