Intracellular signalling and cancer: complex pathways lead to multiple targets

Bell, H. and Ryan, K. (2005) Intracellular signalling and cancer: complex pathways lead to multiple targets. European Journal of Cancer, 41(2), pp. 206-215. (doi:10.1016/j.ejca.2004.10.022)

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Publisher's URL: http://dx.doi.org/10.1016/j.ejca.2004.10.022

Abstract

Normal cells proliferate, die and differentiate as and when they should for the proper functioning of any particular tissue type. These processes are governed by a complex series of intracellular pathways that have many internal checkpoints and safety nets. These ensuring a fine, but tight, balance on overall tissue growth and distribution. A series of key aberrations, resulting in the disruption of these intracellular pathways, can lead to the development of a malignancy. The nature of these alterations is often not only tumour-specific, but also different between individuals with the same tumour type. As a result, these pathways have to be carefully dissected and functionally assessed to identify valid targets with therapeutic potential in a wide range of tumour types

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Bell, H., and Ryan, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:European Journal of Cancer
ISSN:09598049

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