Lamellipodia and filopodia in metastasis and invasion

Machesky, L. (2008) Lamellipodia and filopodia in metastasis and invasion. FEBS Letters, 582(14), pp. 2102-2111. (doi:10.1016/j.febslet.2008.03.039)

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Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2008.03.039

Abstract

Advances in our understanding of the mechanisms of lamellipodia and filopodia assembly have led to a better concept of how cells move, including how the actin cytoskeleton might be important for the motility of metastatic cancer cells. The cytoskeleton is a potentially interesting target for prevention of invasion and metastasis. As key proteins are uncovered which regulate the assembly of actin-based structures, these need to be considered in light of whether they represent potential invasion and metastasis proteins.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Machesky, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:FEBS Letters
ISSN:00145793

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