Rab5 and Rac Team Up in Cell Motility

Zech, T. and Machesky, L. (2008) Rab5 and Rac Team Up in Cell Motility. Cell, 134(1), pp. 18-20. (doi: 10.1016/j.cell.2008.06.039)

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Publisher's URL: http://dx.doi.org/10.1016/j.cell.2008.06.039


Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Zech, Mr Tobias and Machesky, Professor Laura
Authors: Zech, T., and Machesky, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell

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