Chemotaxis in Dictyostelium: how to walk straight using parallel pathways

Insall, R. and Andrew, N. (2007) Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. Current Opinion in Microbiology, 10(6), pp. 578-581. (doi:10.1016/j.mib.2007.10.004)

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Publisher's URL: http://dx.doi.org/10.1016/j.mib.2007.10.004

Abstract

Dictyostelium is one of the most successful and best-studied organisms for research into the mechanisms that drive chemotaxis. In this review, we discuss recent progress in the field. Phosphatidylinositol 3-kinase (PI 3-kinase), previously thought by some to be essential for chernotaxis, has now been proven to be dispensable. However, other pathways are emerging which might connect signalling to migration. In particular, phospholipase A2 homologues appear to play an important role. Other areas of current interest include the fundamental processes by which cells move - pseuclopods have been found to be generated in many different ways. Similarly, chernotaxis may be mediated by multiple checks on the number of pseuclopods, rather than by simple generation of new pseuclopods on demand. Finally, we review several advances in the theory of how cells convert shallow, noisy chemical gradients into overt movement.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Insall, R., and Andrew, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Microbiology
ISSN:13695274

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