Understanding eukaryotic chemotaxis: a pseudopod-centred view

Insall, R. H. (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nature Reviews Molecular Cell Biology, 11(6), pp. 453-458. (doi: 10.1038/nrm2905)

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Publisher's URL: http://dx.doi.org/10.1038/nrm2905


Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Insall, R. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Reviews Molecular Cell Biology
Publisher:Nature Publishing Group
ISSN (Online):1471-0080
Published Online:06 May 2010
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
506871Computational modelling of cell movement and chemotaxisRobert InsallMedical Research Council (MRC)G0802579Beatson Institute for Cancer Research