Frezza, C. and Gottlieb, E. (2009) Mitochondria in cancer: Not just innocent bystanders. Seminars in Cancer Biology, 19(1), pp. 4-11. (doi: 10.1016/j.semcancer.2008.11.008)
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Publisher's URL: http://dx.doi.org/10.1016/j.semcancer.2008.11.008
Abstract
The first half of the 20th century produced substantial breakthroughs in bioenergetics and mitochondria research. During that time, Otto Warburg observed abnormally high glycolysis and lactate production in oxygenated cancer cells, leading him to suggest that defects in mitochondrial functions are at the heart of malignant cell transformation. Warburg's hypothesis profoundly influenced the present perception of cancer metabolism, positioning what is termed aerobic glycolysis in the mainstream of clinical oncology. While some of his ideas stood the test of time, they also frequently generated misconceptions regarding the biochemical mechanisms of cell transformation. This review examines experimental evidence which supports or refutes the Warburg effect and discusses the possible advantages conferred on cancer cells by 'metabolic transformation'.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Frezza, Mr Christian and Gottlieb, Professor Eyal |
| Authors: | Frezza, C., and Gottlieb, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Seminars in Cancer Biology |
| ISSN: | 1044579X |
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