Bioactive ceramic-reinforced composites for bone augmentation

Tanner, K.E. (2010) Bioactive ceramic-reinforced composites for bone augmentation. Journal of the Royal Society: Interface, 7(Suppl.), S541-S557. (doi: 10.1098/rsif.2010.0229.focus)

Abstract

Biomaterials have been used to repair the human body for millennia, but it is only since the 1970s that man-made composites have been used. Hydroxyapatite (HA)-reinforced polyethylene (PE) is the first of the ‘second-generation’ biomaterials that have been developed to be bioactive rather than bioinert. The mechanical properties have been characterized using quasi-static, fatigue, creep and fracture toughness testing, and these studies have allowed optimization of the production method. The in vitro and in vivo biological properties have been investigated with a range of filler content and have shown that the presence of sufficient bioactive filler leads to a bioactive composite. Finally, the material has been applied clinically, initially in the orbital floor and later in the middle ear. From this initial combination of HA in PE other bioactive ceramic polymer composites have been developed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tanner, Professor Kathleen
• Authors: Tanner, K.E.
• Subjects: R Medicine > RD Surgery
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Journal of the Royal Society: Interface
• Publisher: The Royal Society
• ISSN: 1742-5689
• Published Online: 01 June 2010
• Copyright Holders: Copyright © 2010 The Royal Society
• First Published: First published in Journal of the Royal Society: Interface
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher