Zou, H., Mellon, S., Syms, R.R.A. and Tanner, K.E. (2006) 2-dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. Biomedical Microdevices, 8(4), pp. 353-359. (doi: 10.1007/s10544-006-9818-4)
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Publisher's URL: http://dx.doi.org/10.1007/s10544-006-9818-4
Abstract
A fixed microelectrode device for cell stimulation has been designed and fabricated using micro-electro-mechanical systems (MEMS) technology. Dielectrophoretic forces obtained from non-uniform electric fields were used for manipulating and positioning osteoblasts. The experiments show that the osteoblasts experience positive dielectrophoresis (p-DEP) when suspended in iso-osmotic culture medium and exposed to AC fields at 5 MHz frequency. Negative dielectrophoresis (n-DEP) is obtained at 0.1 MHz. The viability of osteoblasts under dielectrophoresis has been investigated. The viability values for cells exposed to DEP are nearly three times higher than the control values, indicating that dielectrophoresis may have an anabolic effect on osteoblasts.
| Item Type: | Articles |
|---|---|
| Keywords: | Micro-electro-mechanical systems, dielectrophoresis, osteoblasts. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tanner, Professor Kathleen |
| Authors: | Zou, H., Mellon, S., Syms, R.R.A., and Tanner, K.E. |
| Subjects: | R Medicine > R Medicine (General) T Technology > TJ Mechanical engineering and machinery |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Biomedical Microdevices |
| ISSN: | 1572-8781 |
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