p53 and metabolism

Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi:10.1038/nrc2715)

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Publisher's URL: http://dx.doi.org/10.1038/nrc2715

Abstract

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin and Vousden, Karen
Authors: Vousden, K., and Ryan, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Reviews Cancer
ISSN:1474-175X

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