New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D. , Pimlott, S.L. and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi: 10.1016/j.bmcl.2009.12.061)

Abstract

With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (Ki 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Pimlott, Dr Sally and Dewar, Dr Deborah and Sutherland, Professor Andrew
• Authors: Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L., and Sutherland, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience; College of Science and Engineering > School of Chemistry
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• ISSN: 0960-894X
• ISSN (Online): 1464-3405
• Published Online: 01 January 2010